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New research to be presented at the European Congress on Obesity (ECO 2025) suggests that weight loss treatments using GLP-1 and dual GLP-1/GIP receptor agonists can lead to significant fat loss with minimal reduction in lean muscle mass

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Glp1r knockdown (KD), 1.0 10 12 vector genomes ml 1 with 0.05% Fast Green) into the left NG with a BJ-110 microinjector (BEX, Tokyo, Japan)

In studies comparing repaglinide monotherapy with sulfonylurea or metformin therapy the decrease in A1c was similar (42,44)

This suggests inhibition of vagal cholinergic input into the stomach with a concomitant increase in gastric volume, though the exact mechanism is not clear

The active ingredient behind both these drugs is tirzepatide