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For patients with TIIDM who do not respond well to sulfonylureas, continuous intravenous infusion of GLP-1 significantly lowers blood glucose levels

This method has been widely used in polypeptide and protein drugs, especially for oral delivery

(doi:10.1126/scitranslmed.aad3744) [DOI] [PMC free article] [PubMed] [Google Scholar] Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, et al
[Google Scholar] Viljoen A., Hoxer C
