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Semaglutide for weight loss is administered as a once-weekly injection, starting at a low dose and increasing gradually over 16+ weeks

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This review will outline the physiology and pharmacological potential of amylin and GLP-1, respectively, and focus on innovative peptide drug development leading to drugs acting on two or more distinct receptors, such as an amylin and GLP-1 peptide hybrid, potentially producing a more effective treatment strategy to combat the rapidly increasing global obesity.