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Actionable next steps for researchers: Define the primary metabolic endpoint before compound selection weight/adiposity studies favour tirzepatide
Sex divergence in blood glucose control exerted by GLP-1 analogs, as indicated by hemoglobin A1c improvements, is less consistent than what was found for body weight effects of these drugs, although more studies report a more pronounced response in females (54-57, 65-68) as compared to those finding a higher percentage of males reaching target hemoglobin A1c (55) or no sex difference (56, 69, 70)
[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Cao Y, Tong Q

These findings support the continued development of retatrutide as a potential treatment option for type 2 diabetes, with ongoing phase 3 trials set to further evaluate its efficacy and safety
