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This hormonal interplay means that two patients using identical microdosing amounts may experience very different outcomes based on their unique hormonal profiles, underscoring the importance of individualized dosing and close monitoring

4 In addition to its effects on glucose, metformin has been shown to have anti-inflammatory properties via inhibition of the nuclear factor B and mammalian target of rapamycin (mTOR) pathways, leading to decreased production of cytokines associated with T helper (Th) 1 and Th17 cell responses, such as IL-17, interferon gamma (IFN-), and tumor necrosis factor (TNF-)

Endocrinology 136: 35853596

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