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Exclusion criteria observed in Phase 2 trials included individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, given the class-level concern with GLP-1 receptor agonists and C-cell tumours in rodent models [8]

Thus, the conjugate did not appear to interfere with the hypothalamic-pituitary-gonadal axis

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