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A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia

They also slow gastric emptying so food moves slower through the stomach

KooijmanSWangYParlevlietETBoonMREdelschaapDSnaterseGet al

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

What Patients Should Know Oral GLP-1 medications can be a helpful tool, but theyre not a one-size-fits-all solution

This includes studying their absorption, distribution, metabolism, and excretion in the body, which dictates their bioavailability and efficacy