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Acolo, Tirzepatide este comparat direct cu Semaglutide la pacieni tratai cu metformin i arat o scdere mai mare a HbA1c i o reducere mai pronunat a greutii corporale, ceea ce susine conceptul c activitatea dubl (GIP/GLP-1) poate avea un efect metabolic suplimentar fa de GLP-1 utilizat singur
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In addition, activating GLP-1R protected mitochondria against the TGF-1+IL-1-induced increase in oxidative phosphorylation in fibroblasts
