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Abbreviations AEs: Adverse events NAEs: Neurological adverse events FDA: The Food and Drug Administration FAERS: The FDA Adverse Event Reporting System GLP-1 RAs: Glucagon-like peptide-1 receptor agonists ADRs: Adverse drug reactions PTs: Preferred Terms SOCs: System Organ Classes IQR: Interquartile range ROR: Reporting odds ratio CI: Confidence interval PRR: Proportional reporting ratio BCPNN: Bayesian Confidence Propagation Neural Network EBGM: Empirical Bayesian geometric mean EBGM05: The lower limit of 95% CI of EBGM IC: Information component IC025: The lower limit of 95% CI of the IC VANs: Vagal afferent neurons T2DM: Type 2 diabetes mellitus OR: Odds ratios References Targher, G., Mantovani, A

Sitagliptin inhibits DPP4, the enzyme that breaks down incretin hormones

This approach is designed to meet regulatory expectations and, at the same time, reduce two foreseeable risks: inadvertent early pregnancy exposure and metabolic rebound after cessation
GLP-1R agonists (GLP-1 receptor) also promote insulin biosynthesis, -cell proliferation and stimulate exocrine or precursor cells to further differentiate the -cell phenotype

Talk to your health care provider about which one is right for you.
