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SURMOUNT-5: The Head-to-Head Trial The SURMOUNT-5 trial compared Zepbound and Wegovy directly over 72 weeks in 751 adults with obesity or overweight, without diabetes

With microdosing tirzepatide , the gradual increase allows your body to adjust at a comfortable pace, which is especially helpful for women in perimenopause , menopause , and postmenopause

Food, drink, smoking, and even pH levels in the mouth affect absorption

Neuropsychiatric symptoms such as depression, irritability, and personality changes may also occur

"Long-term data beyond two to three years are still accumulating," Srivastava says

Against Phentermine/Topiramate, Tirzepatide demonstrated a significant association only with dry eye disease (HR 0.29, 95% CI: 0.150.57, p = 1.3 10 4 ), while other outcomes including cataracts (HR 0.76, 95% CI: 0.381.52, p = 0.433) and oculomotor binocular dysfunction (HR 0.63, 95% CI: 0.341.16, p = 0.134) showed non-significant trends