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Treatment duration in older patients should balance weight loss benefits against the risk of excessive lean mass depletion

Weight loss was a noticeable and serendipitous side effect that took the medical community by storm

Variants like GIPR rs1800437 affect GIP receptor function and predict differential response to tirzepatide versus semaglutide

[DOI] [PMC free article] [PubMed] [Google Scholar] [201].Baekdal TA, Thomsen M, Kupcova V, Hansen CW, Anderson TW, Pharmacokinetics, Safety, and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment, Journal of clinical pharmacology, (2018)

doi: 10.1016/j.diabres.2017.12.008 21 MajumdarSRJosseRGLinMEurichDT

Administration of yerba mat induced significant increases in GLP-1 levels and leptin levels, generating anorexic effects by direct induction of satiety