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Wegovy is started at a lower dose (0.25mg) and gradually increased over several weeks to the maintenance dose of 2.4mg to minimise gastrointestinal side effects

This simple "start low, go slow" strategy is key for two main reasons: minimizing side effects and finding your unique effective dose

and phase-advances diurnal rhythms of feeding and metabolism into the light cycle, and abolishes the normal increase in dark-cycle locomotor activity [27]

Does It Work for Weight Loss

While its clinical benefits command enormous attention, the enzymatic engineering required to manufacture this peptide at scale is a fascinating story in its own right

The STEP-1 Extension trial published in the New England Journal of Medicine found that patients regained approximately two-thirds of lost weight within one year of stopping semaglutide