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Deze bieden langdurige effectiviteit zonder de significante bijwerkingen die gepaard gaan met off-label medicatiegebruik

N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

There is substantial evidence that weight loss improves nearly all components of the lipid profile with sustained benefits for weight loss maintenance [23, 24]

A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm

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