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Exp Clin Endocrinol Amp Diabetes (2022) 130:35867

Following treatment withdrawal, semaglutide participant's regained two-thirds of their prior weight reduction, with net losses of 5.6 % at week 120 compared to baseline with similar changes in cardiometabolic variables (lipid levels, glycemic control, blood pressure and inflammatory markers) [171]

In a surgically induced-OA model in rats, liraglutide also attenuated rat cartilage degeneration through suppressing the release of inflammatory mediators and protected chondrocytes against endoplasmic reticulum (ER) stress and apoptosis induced by interleukin-1 (IL-1) or triglycerides [46]

Wolfgang Marik: declares no conflict of interest relevant to this study

Your doctor may need to adjust your GLP-1 dose, temporarily discontinue therapy, or investigate alternative causes for your symptoms
