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In addition, the insulin release stimulated by GLP-1 is glucose-dependent

Related Reading Oral Semaglutide Weight Loss Semaglutide For Weight Loss 2 Semaglutide Tablets For Weight Loss Semaglutide Pills For Weight Loss Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

Interpretation of Results Efficacy There is clear and consistent evidence from 4 placebo-controlled DB RCTs that semaglutide evokes a statistically significant weight loss that is also clinically significant according to the clinical expert consulted by CADTH on this review

Herrmann, I

Peak results emerge around 1620 weeks as doses escalate and lifestyle changes take root

In the trial, participants who were 50 years of age or older, had type 2 diabetes with a glycated hemoglobin level of 6.5 to 10.0%, and had known atherosclerotic cardiovascular disease, chronic kidney disease, or both received either once-daily oral semaglutide (maximal dose, 14 mg) or placebo, in addition to standard care