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8 It is unclear whether this retinopathy is a true adverse effect related to a molecule-specific effect of semaglutide or whether it relates to rapid marked reduction in glucose, such as originally described in the Diabetes Control and Complications Trial

Efficacy and safety of once-daily oral semaglutide 25 mg and 50 mg compared with 14 mg in adults with type 2 diabetes (PIONEER PLUS): A multicentre, randomised, phase 3b trial

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Combination therapy of DPP4is with SGLT2is has been shown to have the potential to reduce sBP in a previous clinical trial 39 , thus supporting our hypothesis

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The effect is modest at the individual level but statistically robust across nearly 28,000 patients and replicated in an independent NIH All of Us cohort