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8 In part, its benefit is also derived from lower body weight allowing less stress on the joints
The largest ongoing trial is STIMULUS, a multi-site study sponsored by the National Drug Abuse Treatment Clinical Trials Network
In the Phase 3 TRIUMPH-4 trial, 33% of participants on the 12 mg dose reported diarrhea compared to 13.4% on placebo (Wang et al., Syst Rev Meta-Analysis, 2025)
The best approach for managing PCOS symptoms varies because it depends on individual circumstances
These fixed-ratio combination therapies represent attractive options for some patients
