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These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall

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It promotes the conversion of liver glycogen to glucose and increases gluconeogenesis, as well as enhancing fat breakdown to provide energy

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Subsequent studies then confirmed the presence of GLP-1R in these and other insulinoma cell lines [[369], [370], [371], [372], [373], [374], [375], [376]] as well as in somatostatin-secreting cells [370,375] and in islets isolated from rats [377] and humans [378]