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However, while GLP-1 RAs did not exhibit an increased risk of acute pancreatitis, DPP-4 inhibitors demonstrated a notable risk elevation (rate ratio, 1.75) [53]

GLP-1 medications do not directly suppress or enhance testosterone production or alter TRT pharmacokinetics

Presented at EANM'25 on Wednesday 8 October 2025

Effectiveness: Clinical studies show an average weight loss of 15% of total body weight, with some patients achieving up to 30%

Some patients report decreased alcohol consumption while taking GLP-1 receptor agonists, possibly reflecting effects on reward pathways, but this remains an area of ongoing investigation without established clinical recommendations