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10.1016/S2213-8587(19)30249-9

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This finding demonstrates the robust activity of tirzepatide at the alpha cell GIPR that outweighs inhibitory actions produced by GLP-1R agonism and provides additional evidence that tirzepatide has important activity at the GIPR in human islets

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Industry experts estimate that small-molecule production costs could be 10 to 100 times lower than peptide biologics, a differential with profound implications for drug pricing, insurance coverage, global access, and the long-term sustainability of GLP-1-based obesity treatment

About the review This review aims to simultaneously promote GLP-1 RA research and enhance users' understanding by synthesizing evidence from recent landmark trials, thereby providing a comprehensive picture of the potential of these drugs as more than just metabolic modulators