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In trials of the combination of GLP-1 and GIP agonists, patients lost an average of 25% of their initial body weight at the highest dose. GLP-1 medications, which are available by prescription only and administered by weekly injection, are approved for people with a body mass index above 30, or above 27 with a comorbidity, such as type 2 diabetes, prediabetes, high blood pressure or sleep apnea

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The GLP-1 and GIP components improve insulin secretion and sensitivity, driving blood glucose down

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Seino Y, Fukushima M, and Yabe D, GIP and GLP-1, the Two Incretin Hormones: Similarities and Differences, Journal of Diabetes Investigation 1, no