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and including patients with T2D regardless of weight status

GLP-1 stimulation of adipose tissue monocytes increases IL-6 signaling in adipocytes, leading to increased UCP-1 expression and glucose metabolism [112]

Continued approval for this indication may depend upon demonstration of further clinical benefit in studies

Lixisenatide (1.5 g.kg 1 ), a GLP-1A, decreased glucose and insulin areas under the curves (Moore, Werner, Smith, Farmer & Cherrington, 2013)

Life Science 294 , Zhao, H

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