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At 2 years, GLP-1 RA use was associated with an absolute risk increase for psoriasis of 0.05%, rising to 0.08% at 4 years

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If you normally inject on Saturday and want to inject on Friday instead, you are shortening your interval from 168 hours to approximately 144 hours

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Mathieu C, Dandona P, Gillard P et al (2018) Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (the DEPICT-2 Study): 24-week results from a randomized controlled trial