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Furthermore, in signaling studies that used cell lines with recombinantly expressed human GIPR or GLP-1R, tirzepatide stimulated cyclic adenosine monophosphate (cAMP) accumulation by either receptor with potency similar to that of native GIP and approximately 13-fold weaker than that of native GLP-1 [1]

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A vial at day 30 is not dramatically different from day 28, but a vial at day 60 has meaningfully less active peptide than one at day 14

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