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Description
In 1983, Bell et al

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FGF21 is a newly discovered metabolic hormone produced in multiple tissues and secreted in the fasting state and regulates metabolic responses in the pancreas, liver and adipose tissues (95)

First, this was an open-label, Phase II trial (lacks blinding), the duration of the study and follow-up were short, and thus, no data on hard outcomes, such as CV disease risk reduction and mortality, were analyzed

Finally, vasoactive substances produced by vascular endothelial cells are also important factors in the regulation of blood pressure
