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Efinopegdutide is another GLP-1R and GCGR dual agonist currently under clinical investigation, which is being explored in studies for patients with obesity, type 2 diabetes (T2D), and metabolically associated fatty liver disease/multiple acyl-CoA dehydrogenase deficiency syndrome (MASLD/MASH)

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GLP1-RA: Glucagon-like peptide-1 receptor agonist

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Based on the phosphoproteomics data, we suggest that GLP-1 engages a cAMP-mediated signalling mechanism that involves Ca 2+ cycling proteins and possible other downstream targets, which converges with beta-adrenergic signalling downstream of cAMP