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Its weight-loss effects are primarily achieved through several mechanisms, including central appetite regulation via hypothalamic pathways enhancing satiety, delayed gastric emptying that prolongs postprandial fullness, improvement of insulin sensitivity and metabolic homeostasis, and reduction of visceral and hepatic fat depots, which may alleviate respiratory mechanical burden and metabolic stress in OSAS (34)
Further investigation into receptor pharmacodynamics, neural circuit engagement, and hormonal crosstalk, particularly in the context of emerging dual- and triple-agonist therapies, is essential to unlocking their full therapeutic potential

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2c, Supplementary Fig

Risk of stroke and retinopathy during GLP-1 receptor agonist cardiovascular outcome trials: an eight RCTs meta-analysis
