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Following SSRI discontinuation, patients demonstrated statistically significant improvements in verbal memory (Cohen's d=0.32, p=0.03) and Stroop interference scores (p=0.02), indicating resolution of treatment-associated cognitive deficits

These numbers exceeded the Phase 2 results, partly because the trial ran longer (68 weeks versus 48 weeks) and partly because the dose escalation schedule was refined

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Therefore, conducting studies under thermoneutral conditions may provide a way to evaluate treatment effects in CNS GIPR KO mice independently of body weight defence mechanisms and temperature-associated thermogenesis

[97] In contrast to generics, which may be chemically synthesized versions manufactured using different processes than the original biologic drug, Health Canada confirmed that Plosbrio and Poviztra differ from the existing proprietary drugs Ozempic and Wegovy only in name and packaging, and are unrelated to the generics from a regulatory perspective

Ferdinand KC, White WB, Calhoun DA, Lonn EM, Sager PT, Brunelle R, et al