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While statistically significant, however, the clinical significance is questionable

2019;62:S375

While the benefits of GLP-1 RAs and SGLT2s are clear, older drugs such as metformin and sulfonylureas remain effective affordable and widely available

One study compared them directly and found that gastric emptying half-time was delayed by 52 minutes with lixisenatide (short-acting) but only 25 minutes with liraglutide (long-acting) [2]

"Very low/low calorie diets should be complemented with supplementation