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Description
PMID 17308849
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
Based on patterns from tirzepatide (SURMOUNT-4) and semaglutide (STEP-4), weight regain after stopping GLP-1 class medications is expected
Research on GLP-1 maintenance suggests this may preserve 75%+ of weight loss efficacy while reducing cost and side effect burden
These effects are mediated through the activation of its receptor, GLP-1R, which is extensively distributed across various brain regions, including the NAc, BLA, PFC, and VTA [20]
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