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Li Y, Vaughan KL, Tweedie D, et al

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Others are located in the dorsal raphe nucleus, which produces nearly all of the serotonin used by the forebrainthe same neurotransmitter system targeted by selective serotonin reuptake inhibitors

Karwi QG, Lopaschuk GD

Potential implications of the new pharmacotherapies on obesity management The mean WL in clinical trials with the most efficacious new obesity pharmacotherapies ranges between 15% and 25% at 1 year (and it may be even higher for some agents that have not reached weight plateau at study completion)

Peer review Peer review information Nature Chemistry thanks Daniel Reker and the other, anonymous, reviewer(s) for their contribution to the peer review of this work