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10.1016/j.diabet.2018.09.002 38 MokgalaboniK.LebeloS

In a mechanism of action study that aimed to achieve 10% body weight reduction in participants with obesity who were without T2D, tirzepatide was compared to placebo for sleeping and 24-h energy expenditure and respiratory exchange ratio by utilizing metabolic chambers assessed at baseline and after 18 weeks [56]

Higher doses mean more gastrointestinal symptoms

The tirzepatide before and after data shows similar threshold effects at the 15% mark, reinforcing that this is a physiologically meaningful breakpoint across compound classes

Hormonal and metabolic changes after pregnancy Hormones shift quickly after delivery

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