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For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

Both are in Phase 2 clinical trials, and Pitts said the company will make a decision by the end of the year about which to move forward into late-stage testing

Trizepatide is not a stand-alone solution to obesity and should be combined with a healthy lifestyle for optimal outcomes

Previous work has indicated that patients with HFpEF may experience a reduction in peak oxygen uptake (VO 2 ) of approximately 35% as assessed by cardiopulmonary exercise testing (CPET) when compared to healthy age- and sex-matched controls [10]