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Specific gene variants like GLP1R rs6923761 and GIPR rs1800437 affect receptor sensitivity and downstream signaling efficiency, meaning some individuals see rapid, pronounced appetite reduction while others experience more gradual changes

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All patients received 5 mg of oral semaglutide once daily for the first 5 days, then received a dose of 10 mg once daily for the remaining 5 days of the study

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Clinicians managing complex cardiometabolic cases should individualize treatment decisions

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