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This article was originally published on WBUR.org

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GLP-1 exerts physiological effects by binding to the GLP-1 receptor (GLP-1R) on target cells

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Hypoxia induces the stabilization of the transcription factors hypoxia-inducible factor-1 (HIF-1) and HIF-2 which is influenced by O 2 -regulated proteins such as prolyl-hydroxylases (PHDs) and factor-inhibiting HIF (FIH) [21]