shortage of glp-1 receptor agonists Impact ADA Guidelines and Medication on Prescribing Trends in the UK: A Time-Series Analysis with Country-Specific Insights Shortage of GLP-1 receptor agonists
Description
As AUD is a heterogeneous disorder with a multifaceted pathophysiology, the possibility that combinations of GLP-1 and other gutbrain axis peptides synergistically reduce alcohol drinking should be explored in future studies

Combined treatment with glucagon-like peptide-1 receptor agonist Exendin-4 and metformin attenuates breast cancer growth

However, the authors noted prior evidence from studies like Bezin et al

J Mol Endocrinol (2020) 65(4):187201

In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF- (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors
Unlike severe caloric restriction, medical weight loss preserves metabolic rate better through hormonal mechanisms
