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1416 Beyond compositional shifts, the functional consequences of dysbiosis are particularly relevant: the microbiota contributes to obesity pathophysiology by driving the production of short-chain fatty acids (SCFAs), modulating bile acid metabolism, and influencing immune and inflammatory pathways

Yes, semaglutide can cause fatigue, particularly during initial treatment due to gastrointestinal side effects, inadequate caloric intake, dehydration, or hypoglycemia when combined with insulin or sulfonylureas

The effect tends to be strongest once you reach a regular maintenance dose

J.SamsonW

For adults over 40, the maintenance phase is not a passive thing it requires conscious decisions about whether to stay on a maintenance dose, taper down, or come off entirely

Weight and measurements