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Description
Given the eminent global opioid crisis, development of GLP-1RA is an important research goal [106]
Gradual escalation gives the nervous system time to adapt incrementally
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To avoid or minimize these effects, the medications are started at a low dose and then ramped up slowly over a few months
Given the strength of these preliminary signals, the field must now shift focus toward conducting well-powered phase 3 RCTs to validate these associations
