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doi: 10.2337/db08-0822

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The most likely candidate within this pathway through which CR mediates its mental health benefits is CREB, as CREB-deficient animals show limited neurophysiological improvements in response to CR (48)

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Studying GLP-1 + GIP + glucagon triple agonism in a single molecule retatrutide

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Although the effects of tirzepatide and GIP-085 on the human GIPR were not assessed in the current study, comparable EC 50 values were observed in human adipocytes expressing the hGIPR ( 45 ), supporting the translational relevance of these findings

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