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doi: 10.1016/J.BRAINRES.2017.10.012

Further animal studies are necessary to clarify the regulatory factors and mechanisms involved in LDLR transcription

Starting protective strategies before shedding occurs can reduce risk by up to 80% in some cases

13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females

And Im like, Oh god, okay. And hes like, What do you mean in your head? And I, and hes like, This is not in your head. Hes like, Let me show you some blood levels

However, research needs to catch up