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If you have them in a food-restricted state, theyll learn the task and perform the task much better. In sum, she said, our working hypothesis is that the central endogenous GLP-1 system modulates motivated behavior, and it does so in a metabolic-state-dependent manner. The axons of the hindbrain GLP-1 neurons innervate many subcortical brain regions, Rinaman said

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Estradiol has an anorexigenic effect by increasing POMC neuronal activity

Nat Rev Rheumatol 21 , 671683 (2025)

He said as part of their ongoing research, they plan to look into other genes that could also be playing a role with weight loss and GLP-1s.

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