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General tips include rotating injection sites, maintaining a consistent weekly dosing schedule, avoiding overeating even when appetite permits, and allowing adequate time for adaptation before increasing the dose

Clinical Trial Evidence: What The Data Shows About Timing And Persistence Large clinical programs for tirzepatide included diabetes and weight management trials with follow-up that often extended to 52 to 72 weeks

New England Journal of Medicine, 357(23), 2359-2370

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payment or honoraria from Columbia University Medical Center, Boston Obesity Course in Obesity medicine and Medical College of Wisconsin

Allergic reactions to individual components are possible, though uncommon