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PATHOPHYSIOLOGY OF DKD DKD arises from a complex interplay of metabolic, inflammatory, and hemodynamic disturbances, differing notably between type 1 and type 2 diabetes mellitus [19,20]

Initial dose: 0.25 mg once weekly Increase to 0.5 mg at four weeks Potentially increase to 1.0 mg at eight weeks Maintenance dose up to 2.4 mg weekly, based on individual response Every step of the semaglutide weight loss program is watched by healthcare professionals

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Musculoskeletal effects Muscle pain , body aches , and joint pain are reported at varying frequencies

In hepatic condition, direct, indirect bilirubin, urine bile pigments and urobilinogen are very high, with very SGPT, SGOT and moderately increased serum alkaline phosphatase