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Zepbound (tirzepatide) has produced the greatest weight-loss results in clinical trials, followed by Wegovy (semaglutide)
The jump from 1mg to 4mg, nearly doubling the weight loss percentage, likely represents the addition of meaningful glucagon receptor engagement

In one trial, those switched to placebo injections not only began to reaccumulate body fat, but their waist circumference also began to revert back to its original size

"It was very exciting to see our results signal and go in the right direction," Tatum said

We observed, that patients who developed PHLF displayed 2.3-fold higher GLP-1 plasma concentrations preoperatively, compared to patients without PHLF ( p = 0.030)
