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doi: 10.1097/01.NAJ.0001016352.54091.a1

While results vary, consistent weight loss of 13 lbs per week is commonly achieved with proper adherence and support

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Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation