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Thus, caution must be exercised in patients with these antecedents

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That either represents a straightforward, equivalent alternative to the brand-name product

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Under DSHEA, supplements are not subject to FDA pre-market approval for safety or efficacy before going to market - which is categorically different from the FDA's drug approval process

In my experience, three things matter more (1) these are chronic-therapy drugs, not a course you complete, so persistence rates drop sharply after 3-6 months once GI side effects (nausea, bloating) show up