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Description
According to the Summary of Product Characteristics (SmPC), these include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Decreased appetite (very common) Vomiting (common, affecting up to 1 in 10 people) Constipation (common) Abdominal pain (common) Dyspepsia (common) Cholelithiasis (common) Headache (common) These gastrointestinal effects typically occur during the initial weeks of treatment or following dose escalation, and often diminish over time as the body adjusts to the medication

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As researchers explore these peptides, a natural question arises: how do they compare

Sitagliptin, anagliptin, gemigliptin, and teneligliptin form class 3 of the DPP-4 inhibitors (see Figure 2) ( Figure 2 The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion ( This article gives an overview on the characteristics of the various DPP-4 inhibitors in clinical use and highlights the positioning of the drug class in the guidelines for the treatment of type 2 diabetes

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[DOI] [PubMed] [Google Scholar] 129.Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, et al
