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Description
SCFA administration decreases energy intake in mice and humans, both directly, by affecting central neurons, and indirectly, through peripheral circuits innervating the hypothalamus [4749]
An overview of major safety and efficacy clinical trials is provided in Tables 1, 2, 3, and 4 to bring context to the mechanistic findings reported herein
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Pharmacodynamic assay Mice were randomized into four groups based on body weight and body fat percentage and were subcutaneously administered one of the following treatments: Negative control (NC, commercially sourced PBS solution)
Hankosky ER, He X, Malik R, et al
doi:10.1001/jamaophthalmol.2024.2296
