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Although such changes are not directly related to pain, they can affect underlying processes, such as inflammation and obesity, which cause pain signs (Abdolahian et al., 2020)

Clinically studied for greater weight loss than GLP-1 alone

GIP (Glucose-dependent insulinotropic peptide): Enhances the secretion of insulin when blood sugar levels rise, further aiding in blood glucose control

While most forms of semaglutide require refrigeration, it is worth noting that Rybelsus, an oral form, can be kept at room temperature

NCT03574597) trial will evaluate semaglutide versus placebo for preventing MACE in patients with established CVD and overweight/obesity, but without T2D

Traditionally, CBT-I is delivered by sleep-trained psychologists or therapists over the course of 6 to 10 weekly sessions 8