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Some interactions may require close monitoring and/or a dosage adjustment

Mounjaro and Zepbound work similarly, but they use tirzepatide (rather than semaglutide) to simulate both GLP-1 and a second hormone, GIP

This difference may help explain why the pill produces somewhat less weight loss in clinical trials, Dr

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But the difference isn't just about numbers

These include elucidating underlying mechanisms, identifying reliable predictors of therapeutic response, and defining benefits in populations underrepresented or excluded from clinical trials [134,135]